A study found that hypothalamic stem cells in mice responsible for fast aging process. The hypothalamus stem cells known to regulate important processes including growth, development, reproduction and metabolism.
Researchers from the Albert Einstein College of Medicine have discovered that aging in mice is regulated by cells in the hypothalamus. The structure found in vertebrates’ brains that control metabolism and growth. Our research shows that the number of hypothalamic neural stem cells naturally declines over the life of the animal. This decline accelerates aging, senior author Professor Dongsheng Cai said in a statement.
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However, the researchers extracted miRNA-containing exosomes from hypothalamic stem cells and injected them into the cerebrospinal fluid of two groups of mice. Middle-aged mice hypothalamic stem cells had been destroyed and normal middle-aged mice.
Stem cells responsible for anti-aging effects
Moreover, the number of these cells begins to decrease when the rats are 10 months old. Considerably earlier than when the first visible signs of aging appear. But in 24 months the mice considered as very old. Most of these cells gone.
The researchers are now trying to identify the particular populations of microRNAs. Perhaps other factors secreted by these stem cells that are responsible for these anti-aging effects. First step toward possibly slowing the aging process and treating age-related diseases. This treatment significantly slowed aging in both groups of animals. As measured by tissue analysis and behavioral testing that involved assessing changes in the animals’ muscle endurance, coordination, social behavior and cognitive ability.
The team also wondered that hypothalamic stem cells used in reverse to slow down the aging process. The Researchers injected microRNA extracted from the hypothalamic stem cells into the cerebrospinal fluid of the control mice and the middle-aged mice whose hypothalamus had been disrupted.
Aging in both groups to slow down, measured by assessing coordination, muscle endurance, social behavior, and cognitive ability.
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Furthermore, researchers are now looking into exactly how the microRNA molecules help to fight the aging process. Apart from an apparent youth elixir, these molecules could be pivotal to fight age-related degenerative diseases.