“Myths” About An Experimental Chemical Compound Activates An \’exercise Sensor\’ Protein May Actually Be Right


An experimental chemical compound

A study has identified a protein senses when the body exercising and act on the blood vessels to influence circulation. According to research, the researchers experimented with “Yoda1,” a chemical compound that activates this protein.

Researchers led by Prof. David Beech, from the University of Leeds in the United Kingdom, identified a protein that plays main role in regulating blood flow during exercise.

The ability to activate this protein helps to tackle cardiovascular diseases as well as type 2 diabetes. With this reason, the researchers investigated a compound that stimulates the protein.

Physical exercise speeds up the heart rate, means when we are more active, more blood is pumped through the body. To notice that a protein called “Piezo1,” found in the lining of blood vessels, or the endothelium, can perceive this changes in the blood flow and act normally.

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exercise sensor

Piezo1, refers as an “exercise sensor,” which modifies the electrical balance in the lining of the vessels that carry blood from the heart to the stomach and the intestines. These blood vessels placed under an increased pressure when the blood flows boost with exercise, and the action of the Piezo1 protein is vasoconstriction, determining the vessels to narrow down.

The vasoconstriction reduces intestinal and stomach circulation to allow more blood to flow to the brain and the muscles engaged in physical exercise.

According to researchers, the identification of this mechanism helps to conceive new ways of tackling cardiovascular disease, diabetes, and metabolic syndrome, also with the high-risk combination of diabetes, hypertension, and obesity.

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Researchers explain, the benefits supply by physical exercise might be due to this blood flow regulation eased by Piezo1.

Prof. David Beech, said, if we can understand how these bio-molecular systems work, then we may develop techniques that can tackle some of the biggest diseases afflicting modern societies. We know that exercise protects against heart disease, stroke, and many other conditions.

The new study identified a physiological system that senses when the mammalian body is exercising. Also, the study identified the action of Piezo1 in mice, also present in humans, that involves in the same bio-molecular mechanism.

More information: [Nature]