Excess Ibuprofen to impact Male fertility


Researchers have conduced study and found that men consuming 1,200 milligrams of excess ibuprofen a day for six weeks may encounter with reproductive health problems as male fertility.

The study expects further trails and results to prove that reproductive health problems  similar to male fertility are caused in men taking lower doses of excess ibuprofen or whether the effects are reversible. Particularly in men who take ibuprofen for long periods. The study involved 31 men ages 18 to 35 who randomly assigned to take ibuprofen. Two doses of 600 mg each or a placebo every day for six weeks said Bernard Jégou, co-author, director of the National Institute for Research on Environmental and Occupational Health in France

The researchers found the men who took excess ibuprofen experienced a 23 percent increase in levels of luteinizing hormone (LH). A hormone secreted by the pituitary gland and stimulates the production of testosterone after two weeks. Higher-than-normal levels of luteinizing hormone can indicate a problem with the testes as reproductive health problems as male fertility. According to the National Institutes of Health.

Excess Ibuprofen leads to ‘Hypogonadism’ a male fertility problem

However, despite the change in LH levels, the men’s testosterone levels didn’t change. Researchers referred as  “compensated hypogonadism” with levels of testosterone production reduced. But the body is able to compensate by increasing LH levels, the researchers said. Hypogonadism typically found in older men linked with impaired fertility, according to the study.

In the investigation utilizing human testicular tissue in a lab dish likewise recommended that ibuprofen could influence testosterone creation. It’s imperative to take note of that the examination did not take a look at sperm generation. So further investigations expected to look at this, the researchers said.

Individuals consuming control over-the-counter ibuprofen tablets do not take more than 1,200 mg for each day. Unless recommended by a specialist as indicated by Medscape.