Antibiotic Has Been Discovered In The Dirt
Alexander Fleming is a British scientist had invented penicillin, which was the first antibiotic in the world and he has found this in a petri – dish. After ninety years, the world has faced an issue with antibiotics, and it was the resistance made by superbugs.
Also, it was made of drugs in the doctor’s arsenal, and it increases the difficulty in treating the infection. It is also predicted that this antibiotic-resistant will hit 10 million global deaths per year by the year 2050.
So, scientists around the world are sincerely working to invent new microbes to destroy the molecules. But the microbiologist Sean Brady thought to involve in some tactics concerning Fleming. He thought to find the antibiotics on the grounds rather than growing it in Petri dishes.
Brady is also an associate professor in New York and he said that there are at least 10,000 unseen bacteria found in your every step and most of the bacteria are not able to produce molecules. He also added that their idea is to make use of those antibiotics that are present in the environment.
This idea has also earned good results and a study which is recently published said that they had found a new type of antibiotics which is extracted from the microorganism in the soil. This type of antibiotics was called malacidins, and this has the capability of killing plenty of superbugs.
Brady said that this class of molecule would not be found in the next week because it takes several years. To develop, test and to approve a novel molecule, it needs many years, but the discovery of it will be a powerful principle.
Also, the antibiotics are made to be appreciated for their ability to fight with the microbes that cause sickness to humans, and most of the drugs are usually made from bacteria. Bacteria are the one which fight among each other for many years and surprising they are the reason for all the great weapons.
Also, most of the microbes which are treated in laboratories don’t grow well. Brady also said that due to this approach, we missed much chemistry which is being produced by the bacteria and they are the best way to derive many interesting molecules from the environment directly without any chemical process.
So, the researchers can simply focus on doing this, and the team of Brady has cloned from a huge quantity of DNA, which are evolved from hundreds of samples provided by the scientists. They have sorted them with the help of the material, and now they are searching to get some interesting sequences. Brady said they don’t know what is present in that and that will be the future.
Brady and his colleagues are now searching for a new type of gene which can produce antibiotics, which are calcium-dependent and the molecules fight with the bacteria only when they found calcium around it. But it makes the microbes hard to evolve in such resistance. If this gene is injected into microbes, it will produce malacidins. When it is applied to the skin of the infected rats, it sterilized the wounds successfully without causing any side effects. Brady also said that it doesn’t be toxic to the people.
