A bacteria group communicates to avoid antibiotics, says microbiologists


Pseudomonas aeruginosa bacteria group

A team of American microbiologists recently reveals a shocking news about a bacteria. The pathogen, Pseudomonas aeruginosa causes pneumonia, sepsis and other infections. This bacteria group communicates distress signals in response to avoid certain antibiotics.

Researchers said, this communication found across the colony and particularly this bacterium may develop protective behaviors that contribute to its ability to tolerate some antibiotics.

Scientist Nydia Morales-Soto from University of Notre Dame, said, we learn about stationary bio-film communities, whereas less is known about the process before when bacteria are colonizing, spreading and growing. In this study, researchers investigated the behavior of bacteria during this period and what that may mean for antibiotic resistance.

Behavior of bacteria

For testing, researchers used tobramycin, an antibiotic used in clinical settings. They applied this antibiotic to a colony of bacteria Pseudomonas aeruginosa. The bacteria produced a Pseudomonas quinolone signal (PQS) to a localized area of the colony as well as a community-wide response, known as the alkyl hydroxyquinoline (AQNO).

However, the team mapped the production of each response and determined P. aeruginosa can produce PQS in small pockets. Also, they showed PQS and AQNO independently regulated responses that are communicating different messages. Also, the bacteria may have capability to protect the colony from some external toxins while the bacteria are still in a colonizing phase.

The group utilized both Raman spectroscopy and mass spectrometry to complete a deliberate analysis, pixel by pixel, from hundreds of thousands of pixels in their chemical images.

This work opens a new window into understanding the P. aeruginosa behavior and potentially how this bacterium promotes tolerance to antibiotics.